Antibiotic-resistant Salmonella strains not seen in migrating wild birds - petsitterbank

Antibiotic-resistant Salmonella strains not seen in migrating wild birds

“We also showed that lineages formed by wild bird isolates differed from most isolates originating from domestic animal sources,” Dudley said. “And by using a machine learning classifier, we were able to attribute Typhimurium genomes to various groups of wild birds. That’s important because identifying host-adapted genomic datasets can improve source prediction and facilitate future disease outbreak investigation.”

A third paper added to the international aspect of the research, Dudley said. In Microbial Genomics, the researchers reported that they found evidence of common ancestry and evolution of the Salmonella enterica strain Typhimurium in songbirds in the UK and US, presumably resulting from centuries of bird migration.

The researchers analyzed publicly available datasets from the UK, Australia and New Zealand and found that Salmonella strains have been transmitted across the globe. The wild, migrating bird research provides insights into modern-day disease investigations, Dudley suggests.

“To find what antibiotics a particular Salmonella strain is resistant to, we don’t have to run the traditional lab-based tests anymore — where you grow it on some type of media, expose it to antibiotics, and it either grows or it doesn’t ‘t,” he said. “Now, we can sequence the entire genome, and by identifying certain gene markers, we can predict — with almost perfect precision — what antibiotics the organism will be resistant to.”

Also contributing to the research were: Erin Nawrocki, postdoctoral scholar, Department of Food Science, Penn State; Nkuchia M’ikanatha, Pennsylvania Department of Health; Jeffrey Lorch, David Blehert and Brenda Berlowski-Zier, US Geological Survey-National Wildlife Health Center, Madison, Wisconsin; Chris Whitehouse, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, Maryland; Shaoting Li and Xiangyu Deng, Center for Food Safety, Department of Food Science and Technology, University of Georgia, Griffin, Georgia; Jared Smith and Nikki Shariat, Department of Population Health, Poultry Diagnostic and Research Center, University of Georgia, Athens, Georgia.

The US Food and Drug Administration and the US Department of Agriculture supported the study.

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